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2025-01-13 Category: jiliko voucher code philippines
NoneAs part of a national “moonshot” to cure blindness, researchers at the CU Anschutz Medical Campus will receive as much as $46 million in federal funding over the next five years to pursue a first-of-its-kind full eye transplantation. “This is no easy undertaking, but I believe we can achieve this together,” said Dr. Kia Washington, the lead researcher for the University of Colorado-led team, during a press conference Monday. “And in fact I’ve never been more hopeful that a cure for blindness is within reach.” The CU team was one of four in the United States that received funding awards from the federal Advanced Research Projects Agency for Health , or ARPA-H. The CU-based group will focus on achieving the first-ever vision-restoring eye transplant by using “novel stem cell and bioelectronic technologies,” according to a news release announcing the funding. The work will be interdisciplinary, Washington and others said, and will link together researchers at institutions across the country. The four teams that received the funding will work alongside each other on distinct approaches, though officials said the teams would likely collaborate and eventually may merge depending on which research avenues show the most promise toward achieving the ultimate goal of transplanting an eye and curing blindness. Dr. Calvin Roberts, who will oversee the broader project for ARPA-H, said the agency wanted to take multiple “shots on goal” to ensure progress. “In the broader picture, achieving this would be probably the most monumental task in medicine within the last several decades,” said Dr. Daniel Pelaez of the University of Miami’s Bascom Palmer Eye Institute, which also received ARPA-H funding. Pelaez is the lead investigator for that team, which has pursued new procedures to successfully remove and preserve eyes from donors, amid other research. He told The Denver Post that only four organ systems have not been successfully transplanted: the inner ear, the brain, the spinal cord and the eye. All four are part of the central nervous system, which does not repair itself when damaged. If researchers can successfully transplant the human eye and restore vision to the patient, it might help unlock deeper discoveries about repairing damage to the brain and spine, Pelaez said, as well as addressing hearing loss. To succeed, researchers must successfully remove and preserve eyes from donors and then successfully connect and repair the optical nerve, which takes information from the eye and tells the brain what the eye sees. A team at New York University performed a full eye transplant on a human patient in November 2023, though the procedure — while a “remarkable achievement,” Pelaez said — did not restore the patient’s vision. It was also part of a partial face transplant; other approaches pursued via the ARPA-H funding will involve eye-specific transplants. Washington, the lead CU researcher, said she and her colleagues have already completed the eye transplant procedure — albeit without vision restoration — in rats. The CU team will next work on large animals to advance “optic nerve regenerative strategies,” the school said, as well as to study immunosuppression, which is critical to ensuring that patients’ immune systems don’t reject a donated organ. The goal is to eventually advance to human trials. Pelaez and his colleagues have completed their eye-removal procedure in cadavers, he said, and they’ve also studied regeneration in several animals that are capable of regenerating parts of their eyes, like salamanders or zebra fish. His team’s funding will focus in part on a life-support machine for the eye to keep it healthy and viable during the removal process. InGel Therapeutics, a Massachusetts-based Harvard spinoff and the lead of a third team, will pursue research on 3-D printed technology and “micro-tunneled scaffolds” that carry certain types of stem cells as part of a focus on optical nerve regeneration and repair, ARPA-H said. ARPH-A, created two years ago, will oversee the teams’ work. Researchers at 52 institutions nationwide will also contribute to the teams. The CU-led group will include researchers from the University of Southern California, the University of Wisconsin, Indiana University and Johns Hopkins University, as well as from the National Eye Institute . The teams will simultaneously compete and collaborate: Pelaez said his team has communicated with researchers at CU and at Stanford, another award recipient, about their eye-removal research. The total funding available for the teams is $125 million, ARPA-H officials said Monday, and it will be distributed in phases, in part dependent on teams’ success. U.S. Rep. Diana DeGette, a Democrat who represents Denver in Congress, acknowledged the recent election results at the press conference Monday and pledged to continue fighting to preserve ARPA-H’s funding under President-elect Donald Trump’s administration. The effort to cure blindness, Washington joked, was “biblical” in its enormity — a reference to the Bible story in which Jesus cures a blind man. She and others also likened it to a moonshot, meaning the effort to successfully put Neil Armstrong and Buzz Aldrin on the moon nearly 50 years ago. If curing blindness is similar to landing on the moon, then the space shuttle has already left the launchpad, Washington said. “We have launched,” she said, “and we are on our trajectory.”646-ph 。



LAS VEGAS — There are three races remaining in the Formula 1 season and Max Verstappen of Red Bull is close to a fourth consecutive world championship, which can wrap up Saturday night at the Las Vegas Grand Prix. All is not smooth sailing headed into this final month of racing: "It was a bit of a surprise, I think, for everybody," said Mercedes driver George Russell, a GPDA director. "It's a hell of a lot of pressure now onto the new race director (with) just three races left. Often, as drivers, we probably feel like we're the last to find out this sort of information." The Andretti team is expected to receive F1 approval to join the grid, albeit without Michael Andretti, who has scaled back his role dramatically since the IndyCar season ended in September. Many drivers, particularly seven-time champion Lewis Hamilton, have been at odds with FIA President Mohammed Ben Sulayem since his election following the 2021 season finale. In the GDPA statement, they reminded the sanctioning body "our members are adults" who don't need lectures and fines on foul language or jewelry bans, and simply want fair and consistent race control. There's been no response from Ben Sulayem, and won't be this weekend since he does not attend the LVGP. He will be at Qatar and the finale in Abu Dhabi next month. Hamilton doesn't think all the behind-the-scenes changes will be a fan topic as the season comes to a close. But he noted that consistency from race control is all the drivers have asked for, while throwing his support behind Domenicali and the job Maffei has done in growing F1 since Liberty took over. "I really hope Stefano is not leaving because he's been so instrumental in changes and progress to this whole thing," Hamilton said. "And he knows the sport as well as anyone. But all good things do come to an end, and whoever they put into place, I just hope they are like-minded. But sometimes you have to shake the trees." That's just what happened with the surprise departure of race director Wittich. Although drivers have been unhappy with race officiating this season and held a private GPDA meeting in Mexico City, Russell said they had no prior warning Wittich was out. The race director is the referee each weekend and Wittich has been in charge since 2022, when Michael Masi was fired following the controversial 2021 season-ending, championship-altering finale at Abu Dhabi. Now the man in charge for the final three races is Rui Marques, the Formula 2 and Formula 3 race director. Las Vegas, which overcame multiple stumbling blocks in last year's debut before putting on one of the best races of the season, is a difficult place to start. Verstappen can win his fourth title by simply scoring three points more than Lando Norris of McLaren. "It's a bit weird with three races to go to do that," Verstappen said. "It doesn't matter if you're positive or negative about certain things. I thought in Brazil there was definitely room for improvement, for example. It's still a bit weird having to now then deal with a different race director." Charles Leclerc of Ferrari wondered why the move was made with only three races to go. "To do it so late in the season, at such a crucial moment of the season, it could have probably been managed in a better way," he said. The drivers have consistently asked for clearer guidelines in the officiating of races, specifically regarding track limits and racing rules. The drivers have no idea how Marques will officiate, highlighting a disconnect between the competitors and Ben Sulaymen's FIA. "We just want to be transparent with the FIA and have this dialogue that is happening," Russell said. "And I think the departure of Niels is also a prime example of not being a part of these conversations." The GDPA statement made clear the drivers do not think their voice is being heard. "If we feel we're being listened to, and some of the changes that we are requesting are implemented, because ultimately we're only doing it for the benefit of the sport, then maybe our confidence will increase," Russell said. "But I think there's a number of drivers who feel a bit fed up with the whole situation. It only seems to be going in the wrong direction." He also said the relationship between the drivers and the FIA seems fractured. "Sometimes just hiring and firing is not the solution," he said. "You need to work together to improve the problem." Norris, who has battled Verstappen this year with mixed officiating rulings, said "obviously things are not running as smoothly as what we would want." Marques has his first driver meeting ahead of Thursday night's two practice sessions and then three weeks to prove to the competitors he is up for the job. Carlos Sainz Jr., who will leave Ferrari for Williams at the end of the season, hopes the drama doesn't distract from the momentum F1 has built over the last five years. "I think Formula 1 is in a great moment right now and all these rumors, I think in every team, every job, there's job changes," he said. "It's not big drama. I'm a big fan of the people you mentioned, they've done an incredible job in Formula 1 and Formula 1 is what it is thanks to these people. But it's just so emotional, especially the Stefano one. The only one that has a real effect is the race director. But I think if he does a good job, it should be transparent and nothing big." Get local news delivered to your inbox!RALEIGH, N.C. (AP) — North Carolina lawmakers on Wednesday enacted a law over the governor's veto that would diminish the powers afforded to his successor and other other Democratic statewide winners in the Nov. 5 elections. In a 72-46 vote, the GOP-dominated House overrode Democratic Gov. Roy Cooper's veto a week after the Republican-controlled Senate voted to do the same. Like during the Senate vote, opponents to the power-shifting bill sat in the gallery and disrupted the chambers' floor proceedings. More than 150 people gathered on the third floor — more than the House gallery could seat. They chanted “shame” as the override vote completed and continued to yell as they were escorted out. After warning disruptors they would face arrest if they didn't quiet down and leave the building, General Assembly police arrested one woman who refused to leave, said police Chief Martin Brock, adding that she would face charges of trespassing, resisting arrest and violating building rules. Many provisions within the 132-page law seek to diminish powers afforded to Gov.-elect Josh Stein, incoming attorney general Jeff Jackson, the next Democratic lieutenant governor and the schools superintendent. They all take office early next month. One of the most significant changes shifts the power to appoint State Board of Elections members from the governor to the state auditor, who will be a Republican next year. For decades, the governor has selected its five members, with the governor’s party usually taking three seats. The enacted law transfers that power to the state auditor starting in spring. This in turn, means Republicans will likely hold majorities on the state board and the county election boards. The legislation also weakens the governor’s authority to fill vacancies on the state Court of Appeals and Supreme Court and prevents the attorney general from taking legal positions contrary to the General Assembly in litigation challenging a law’s validity. Several post-election deadlines will move up under the law after Republican complaints that counties took too long to count provisional and absentee ballots, especially in light of an extremely close Supreme Court race . The veto override took place in the final days of a lame-duck General Assembly session where Republicans hold exactly the number of seats necessary to override vetoes without help from Democrats. That won’t be the case much longer — barring a successful election protest that would flip a race’s result — after Democrats picked up one more House seat in the general elections. Despite ultimately succeeding in their override, House Republicans had some difficulty staying unified. Some GOP lawmakers from western North Carolina — where Hurricane Helene caused historic flooding — initially voted against the measure. But all three — Reps. Mike Clampitt, Karl Gillespie and Mark Pless — ended up voting to override the veto. Part of the criticism levied against the bill centered on the $252 million of Helene recovery funds attached to it, most of which can’t be spent until the General Assembly acts again. In his veto message , Cooper called the bill a sham in which Republicans used Helene and “disaster relief” in its title to mask unconstitutional political power grabs — a message repeated by House Democrats and Stein. “It is despicable for the Republicans in the General Assembly to use folks’ incredible need for aid to cloak their political pettiness,” Stein said in a statement after the vote. Other opponents to the bill said at a Wednesday news conference that GOP lawmakers weren’t serving western North Carolinians and instead were undermining democracy. “Western North Carolina is not a toy to be played with. It is not an opportunity to exploit. It is not a place to be so violently disrespected,” said Sam Stites, a Transylvania County staff member from advocacy group Just Economics of Western North Carolina. Republicans point out they had already allocated more than $900 million to Helene relief since October, with plans for more funding next session. Caldwell County Republican Rep. Destin Hall, who is expected to be the House speaker next year, further defended the bill's executive power shifts as the legislature's constitutional right. “This body is entirely committed to helping folks in this state with storm relief,” he said. “So, in my opinion, what's happened is political football has been made out of this bill.” It's likely the new law will be mired in litigation — just like eight years ago, after Republicans passed laws weakening Cooper’s powers just before he took office. The House also secured for the November 2026 statewide ballot a proposed constitutional amendment to require all North Carolina voters show photo identification before voting. The constitution currently only specifies that it’s required for in-person voting. ID exceptions are afforded now and would continue with the amendment.

iPhone fans predict release date of upcoming iOS 18 update in leaks from cellular provider READ MORE: iOS 18 update causes banking issues for iPhone users By NIKKI MAIN SCIENCE REPORTER FOR DAILYMAIL.COM Published: 21:35, 5 December 2024 | Updated: 21:48, 5 December 2024 e-mail 1 View comments Apple fans are predicting the release date for the new iOS 18.2 update after spotting a clue shared by a cellphone provider. The British mobile network, EE, recently announced that customers wouldn't be able to use their shared number service on MacBooks and iPads starting December 9. The majority of carrier updates are released alongside Apple software updates, meaning that the phone company may have indirectly revealed when iOS 18.2 will be released to all users. The information has set social media a blaze with iPhone users rejoicing about the upcoming iOS date. 'Apple is expected to release iOS 18.2 in December, possibly on Dec. 9,' a user shared on X. 'The update could feature expanded Apple Intelligence capabilities, which is what a lot of us Apple users are eagerly awaiting,' they added. The third iOS 18.2 beta test was released on November 20, which introduced Wi-Fi calling for other devices and new Apple Intelligence features. However, the company hasn't confirmed when all of it's 1.46 billion global customers would receive the update. Apple fans have guessed that the company will publicly release its iOS 18.2 software update on December 9. This is based on a phone carrier's message to its customers saying it would remove its Smart number service Last month, some Apple users had speculated that the iOS 18.2 update would be issued on December 2, but EE's message appeared to indicate a later release. 'Recently received a message from about their Smart Number service ending on 9 December,' one person wrote on X. 'Now, MacRumors suggests this could hint at the iOS 18.2 release date. Any other users seeing this as a sign? Up until now, my money was on 2nd December.' EE told its customers: 'We wanted to let you know that, from 09 December, you'll no longer be able to use your EE shared number service on MacBooks and iPads. 'Watch functionality, along with the Apple-provided iCloud number-sharing function, won’t be affected. 'We’re sorry for any inconvenience caused by this update.' Some iPhone users reported that a December 9 release date would make sense because Apple typically issues its updates on a Monday and doesn't make any new changes to its software during the holiday season. The iOS 18.2 update will include the Image Playground feature (pictured) that lets users create a cartoon-like image from pictures in their photo library or other prompts The update will also include a Genmoji feature which uses text prompts for users to create their own custom emojis The update will introduce new Apple Intelligence features for iPhone 15 Pro and iPhone 16 models including Genmoji, Image Playground and ChatGPT integration for Siri. Read More EXCLUSIVE iPhone expert tests Apple Intelligence features on iOS Genmoji will allow customers to use text prompts create their own custom emoji image which will be accessible through the Messages and Notes apps . Likewise, Image Playground utilizes text descriptions, concepts and pictures from the photo library to create a cartoon illustration on their iPhone. It will also include Visual Intelligence which lets users identify what's around them by using the Camera app which will provide information about nearby stores and restaurants. The update will come with a new writing tool that offers more customization for text message and emails that will automatically generate the tone and format based on the user's prompts. Users expressed their excitement about the new features, with one person touting on X: 'Apple launch iOS 18.2. this is the huge update in iOS history!' iPhone Share or comment on this article: iPhone fans predict release date of upcoming iOS 18 update in leaks from cellular provider e-mail Add comment

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